When you're doing something for the first time, naturally you're gonna run into some aggravating set backs. Example: The left page on this spread.
When I started out with the first few frames, my technique was very meticulous and technical, with lots and lots and lots and lots of layers. But also took vast amount of endurance and making and switching between individually partitioned layers for eyes, skin, hair, different parts of each character's clothing, etc. And was very, very slow.
Needless to say I snapped before that first page was done, and Agent Elrond ended up taking over just in time to do the last frame.
Then I found it was much easier to just free-hand shade each frame, with a single layer devoted to the toning for all the frames (the linework being in a separate layer to it's own), and it was much less painful.